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HIV / AIDS (24)

Adolescent Sexual Health in Europe and the U.S. - Why the Difference?

by Tally on April 4, 2010
Visit http://www.advocatesforyouth.org/index.php?option=com_content&task=view&id=419&Itemid=177

An article in Advocates of Youth that compares data between Europe and the United States.

In France, Germany, and the Netherlands, two things create greater, easier access to sexual health information and services for all people, including teens. They are: 1) societal openness and comfort in dealing with sexuality, including teen sexuality; and 2) pragmatic governmental policies. The result - better sexual health outcomes for French, German, and Dutch teens when compared to U.S. teens.

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  • Circumcision
  • Circumcision Studies
  • HIV / AIDS
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Circumcision among men who have sex with men in Scotland: limited potential for HIV prevention

by Tally-admin on July 8, 2010
Visit http://sti.bmj.com/content/early/2010/06/30/sti.2010.042895.full

A study published Sexually Transmitted Infections, doi:10.1136/sti.2010.042895, determined that there was no association between circumcision and HIV for men having sex with men. The researchers concluded that circumcision is unlikely to be a feasible HIV prevention strategy for gay men in the UK.

This study supports other studies that found no link between circumcision status and HIV infection rates among homosexual men.

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Circumcision and its potential impact on the spread of HIV among gay and bisexual men

by Tally on December 22, 2009
Visit http://www.catie.ca/catienews.nsf/00a48c8905294f0b8525717f00661eb8/1dbb6bf1c2a2134185257690005abebe!OpenDocument

Banner logo for CATIE-News: Bite-sized HIV/AIDS news bulletins published by Canadian AIDS Treatement Information Exchange.CATIE-News: Bite-sized HIV/AIDS news bulletins published by Canadian AIDS Treatement Information Exchange. The page addresses many of the current studies and meta-analysis for HIV and the gay man. The results of the various studies and meta-analysis are consistent and show that there is little to no benefit in circumcising gay men to reduce HIV.

Researchers studying the increase and spread of HIV have concluded in several studies that increases in high-risk sex have overwhelmed any decrease in infectivity due to HAART (highly active antiretroviral therapy). This does not mean that current HIV prevention efforts have failedwithout these efforts, rates of new cases of HIV and STIs might be much higher. This environment of high-risk sex and STIs must be taken into account when considering the potential impact and rollout of new prevention interventions--such as male circumcision, microbicides or pre-exposure prophylaxis (PrEP)--in gay and bisexual men in high-income countries.

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Circumcision and Risk of Sexually Transmissible Infections in a Community‐Based Cohort of HIV‐Negative Homosexual Men in Sydney, Australia

by Tally on November 14, 2009
Visit http://www.journals.uchicago.edu/doi/abs/10.1086/648376

Study published in The Journal of Infectious Diseases, 2009; 200:000–000. DOI: 10.1086/648376. The authors found a correlation of reduced incidence of syphilis among men who reported predominantly insertive unprotected anal intercourse.

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Circumcision in Australia: further evidence on its effects on sexual health and wellbeing

by Tally on April 14, 2010
Visit http://onlinelibrary.wiley.com/doi/10.1111/j.1753-6405.2010.00501.x/abstract

Study published in Australian and New Zealand Journal of Public Health, Vol. 34 Issue 2, Pages 160 - 164 (April 2010).  The study concluded that "Circumcision appears to have minimal protective effects on sexual health in Australia." Translated into English, "Circumcised men do not have any additional protection against sexually transmitted diseases."

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Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial

by Tally on December 11, 2009
Visit http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60998-3/abstract

Study published in The Lancet, Volume 374, Issue 9685, Pages 229 - 237, 18 July 2009. doi:10.1016/S0140-6736(09)60998-3.  The study assessed whether circumcision in HIV-infected men would reduce transmission of the virus to female sexual partners. Circumcision of HIV-infected men did not reduce HIV transmission to female partners over 24 months; longer-term effects could not be assessed. Condom use after male circumcision is essential for HIV prevention.  The results indicate that there is a probability of 21.7% HIV infection rate for female partners of circumcised HIV infected men, compared to 13.4% HIV infection rate for female partners of HIV infected men. Women with circumcised partners had more than a 50% increase in the infection rate of women compared to women with un-circumcised partners.

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  • Circumcision Harm
  • Circumcision Studies
  • HIV / AIDS
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Circumcision in the United States: Prevalence, Prophylactic Effects, and Sexual Practice

by Tally on February 5, 2010
Visit http://jama.ama-assn.org/content/277/13/1052.abstract

Study published in JAMA, 1997; 277(13): 1052-1057. The objective was to assess the prevalence of circumcision across various social groups and examine the health and sexual outcomes of circumcision. The authors analyzed the National Health and Social Life Survey (NHSLS) data to determine the effects of circumcision. The results indicate, "We find no significant differences between circumcised and uncircumcised men in their likelihood of contracting sexually transmitted diseases." 

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Circumcision not enough to stop HIV, experts warn experts

by Tally on October 25, 2009
Visit http://www.nation.co.ke/News/-/1056/663870/-/uneiet/-/

The Daily Nation, a Kenyan news site, reports on September 26, 2009, that recent findings show an increase in HIV infection in regions where most males are circumcised.

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Future HIV Therapy: Male circumcision is not the HIV ‘vaccine’ we have been waiting for!

by Tally on June 2, 2010
Visit http://www.futuremedicine.com/doi/full/10.2217/17469600.2.3.193

Article published in Future Medicine, Vol. 2, No. 3, pp. 193-199 , May 2008. DOI 10.2217/17469600.2.3.193 The authors examine the three randomized clinical trials (RCTs) conducted in Africa and find them wanting. A recent commentary claims that circumcision is "at least as good as the HIV vaccine we have been waiting for, praying for and hoping to see in our lifetimes." The article provides an analysis that refutes that statement.

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HIV infection and circumcision: cutting through the hyperbole

by Tally on October 26, 2009
Visit http://rsh.sagepub.com/cgi/content/abstract/125/6/259

Published in The Journal of the Royal Society for the Promotion of Health, Vol. 125, No. 6, 259-265 (2005) (DOI: 10.1177/146642400512500607). The authors conclude, "Even if effective, mass circumcision as a preventive measure for HIV in developed countries is difficult to justify."

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HIV-1 Interactions and Infection in Adult Male Foreskin Explant Cultures

by Tally on December 7, 2009
Visit http://www.retroconference.org/2009/Abstracts/35027.htm

Paper from 16th Conference on Retroviruses and Opportunistic Infections (2009).  A pdf file of the paper is available on the website.

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How the circumcision solution in Africa will increase HIV infections

by Tally on April 18, 2011
Visit http://www.publichealthinafrica.org/index.php/jphia/article/viewArticle/jphia.2011.e4/html_9

Journal of Public Health in Africa: How the circumcision solution in Africa will increase HIV infectionsPaper published in Journal of Public Health in Africa,  Vol 2, No 1 (2011); 2:e4. doi:10.4081/jphia.2011.e4

The article was authored by Dr. Robert S. Van Howe, a pediatrician who has studied the harmful effects of infant circumcision. In this paper, Dr. Van Howe examines the oft-cited randomized clinical trials (RCTs) performed in Africa.

Based on the evidence collected in the RCTs and presented in the numerous studies based on the RCTs, Dr. Van Howe determined that the published results are overstated and unsupported by the evidence. He concludes that the "circumcision solution is a wasteful distraction that takes resources away from more effective, less expensive, less invasive alternatives. By diverting attention away from more effective interventions, circumcision programs will likely increase the number of HIV infections."

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  • Circumcision Studies
  • HIV / AIDS
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Langerhans cells limit HIV invasion

by Tally on November 27, 2009
Visit http://jcb.rupress.org/content/177/1/5a.full

Note published in The Journal of Cell Biology, Vol. 177, No. 1, 5 (March 2007), doi:10.1083/jcb.1771rr5, refers to de Witte* study in Nat. Med. doi:10.1038/nm1541. Further research shows that a suspected entry route for HIV is a dead end. Langerhans cells, rather than transmitting the virus to T cells, trap HIV-1 and thus act as a barrier to infection. The foreskin of the male penis has Langerhans cells, but they are removed, along with the foreskin, during circumcision.

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Male Circumcision and HIV Prevention: Insufficient Evidence and Neglected External Validity

by Tally on June 12, 2011
Visit https://www.ajpmonline.org/article/S0749-3797(10)00439-3/fulltext

Article in American Journal of Preventive Medicine, Volume 39, Issue 5 , Pages 479-482, November 2010. The authors discuss the "external validity" of the three African randomized control trials that examined circumcision as a preventive measure for HIV infection. The nutshell version of this discussion is that clinical conditions that show promise do not necessarily translate into a real world net benefit.

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Male Circumcision and HIV: A Public Health Policy Weblog

by Tally on November 5, 2009
Visit http://www.circumcisionandhiv.com/

The Male Circumcision and HIV blog presents current information on policy decisions and various actions by organizations that can affect policy.

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  • HIV / AIDS
  • Intactivism (Pro-Intact)
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Michael Fumento: The Myth of Heterosexual AIDS - A Nine-Year Retrospective of Fear and (Mostly) Loathing

by Tally on April 14, 2010
Visit http://fumento.com/aids/pozaids.html

A well-researched article by Michael Fumento describing the transmission vectors of AIDS, as backed up by statistics. The author notes that much dis-information is promulgated regarding heterosexual AIDS. Citing statistics, Fumento notes that there are few cases of heterosexual AIDS that withstand scrutiny.

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Minimal impact of circumcision on HIV acquisition in men who have sex with men

by Tally-admin on November 10, 2010
Visit http://www.publish.csiro.au/nid/164/paper/SH09080.htm

Paper published in Sexual Health, 7(4) 463–470, November 2010. doi:10.1071/SH09080. The authors developed a mathematical model to simulate HIV propagation within a MSM population. Conclusions: "The results of these calculations suggest that circumcision as a public health intervention will not produce a substantial decrease in HIV prevalence or incidence among MSM in the near future, and only modest reductions are achievable in the long-term."

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Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia

by Tally on October 15, 2011
Visit https://onlinelibrary.wiley.com/doi/full/10.1111/j.1753-6405.2011.00761.x

Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in AustraliaAn article published in the Australian and New Zealand Journal of Public Health, Volume 35, Issue 5, pages 459–465, October 2011. DOI: 10.1111/j.1753-6405.2011.00761.x

Objective: To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection.
 

Approach: These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence-based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues.
 

Conclusion: Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random-controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random-controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a ‘surgical vaccine’ is criticised as polemical and unscientific.

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  • Circumcision Studies
  • HIV / AIDS

Prevalence and Risk Determinants of Human Immunodeficiency Virus Type 2 (HIV-2) and Human Immunodeficiency Virus Type 1 (HIV-1) in West African Female Prostitutes

by Tally on January 2, 2010
Visit http://aje.oxfordjournals.org/content/136/7/895.abstract

Study published in American Journal of Epidemiology, Vol. 136, No. 7: 895-907 (1992). The authors found that "a history of excision and BCG vaccinations decreased the risk of HIV-2 infection." That is, women who had undergone female genital cutting had reduced risk of HIV infection.

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  • Female Circumcision (FGM)
  • HIV / AIDS
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Prevalence of male circumcision and its association with HIV and sexually transmitted infections in a U.S. navy population

by Tally on September 10, 2011
Visit http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102282676.html

Study published in International Conference on AIDS, 15th : 2004 : Bangkok, Thailand, July 11-16: abstract no. TuPeC4861. The Naval Health Research Center conducted a study of men assigned to aircraft carriers. The results showed that "lack of circumcision was not found to be a risk factor for HIV."

Conclusion: Male circumcision "is not associated with HIV or STI prevention in this U. S. military population."

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Scarification and Male Circumcision Associated with HIV Infection in Mozambican Children and Youth

by Tally on September 25, 2011
Visit http://www.webmedcentral.com/article_view/2206

A study published in WebmedCentral Epidemiology, 2011;2(9):WMC002206, by Dr. Devon D Brewer. The study examined the association between male circumcision, scarification, and HIV infection in Mozambican children and youth with data from the 2009 Mozambique AIDS Indicator Survey. The study provides compelling evidence that male circumcision of infants and children, even if done in a medical setting, results in a higher rate of HIV infection for the males than if they remain intact. The study also calls into question studies that do not apply rigorous standards for controlling for other causes of HIV infection.

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Sexually Transmitted Infections and Male Circumcision: A Systematic Review and Meta-Analysis

by Tally on May 1, 2013
Visit https://www.hindawi.com/isrn/urology/2013/109846/

ISRN Urology, Volume 2013 (2013), Article ID 109846, 42 pages, http://dx.doi.org/10.1155/2013/109846 Sexually Transmitted Infections and Male Circumcision: A Systematic Review and Meta-Analysis

An article by Robert S. Van Howe of the Department of Pediatrics and Human Development, Michigan State University College of Human Medicine. He performed a systematic review and meta-analyses of studies to determine the effects of male circumcision on various sexually transmitted diseases (STDs). From the Abstract:

Chlamydia, gonorrhea, genital herpes, and human papillomavirus are not significantly impacted by circumcision. Syphilis showed mixed results with studies of prevalence suggesting intact men were at great risk and studies of incidence suggesting the opposite. Intact men appear to be of greater risk for genital ulcerative disease while at lower risk for genital discharge syndrome, nonspecific urethritis, genital warts, and the overall risk of any sexually transmitted infection. In studies of general populations, there is no clear or consistent positive impact of circumcision on the risk of individual sexually transmitted infections. Consequently, the prevention of sexually transmitted infections cannot rationally be interpreted as a benefit of circumcision, and any policy of circumcision for the general population to prevent sexually transmitted infections is not supported by the evidence in the medical literature.

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  • HIV / AIDS
  • HPV
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Size Matters: The Number of Prostitutes and the Global HIV/AIDS Pandemic

by Tally on November 17, 2009
Visit http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000543

A study published at PLoS ONE 2(6): e543. doi:10.1371/journal.pone.0000543. "This paper provides strong evidence that when conducted properly, cross country regression data does not support the theory that male circumcision is the key to slowing the AIDS epidemic. Rather, it is the number of infected prostitutes in a country that is highly significant and robust in explaining HIV prevalence levels across countries." The article received several critical comments, including one by Halperin. The article's author John R. Talbott provides a very good rebuttal attacking the Africa trials' statistical analysis methodology.

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YouTube: Dr. Dean Edell AIDS - Circumcision Fallacy

by Tally on October 22, 2009
Visit http://www.youtube.com/watch?v=OlsUg0sdAtE

Dr. Dean Edell discusses the misleading and unsound arguments in the current drive to circumcise Africa. See the video below.

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Restoring Tally is just an ordinary guy who had to confront his prostate and circumcision problems. This site chronicles his journey in dealing with these issues. He has had prostate surgery and he is restoring his foreskin.

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